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Paclitaxel

Paclitaxel

Basic Information

CAS No.:33069-62-4
Molecular Formula:C47H51NO14
Molecular Weight: 853.92

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Product Details

Paclitaxel, a natural product isolated from the bark of the Pacific yew, is effective in treating refractory metastatic ovarian cancer.  Unlike any other antineoplastic agents, paclitaxel appears to have several possible mechanisms of action, including an antimicrotubule action through the promotion of tubulin polymerization and stabilization of microtubules, thereby, halting mitosis and promoting cell death.


Chemical Properties
PropertyValue

Melting point

213 °C (dec.)(lit.)

Alpha

D20 -49° (methanol)

Boiling point

774.66°C (rough estimate)

Density

0.200

Refractive index

-49 ° (C=1, MeOH)

Fp

9℃

Storage temp.

2-8°C

Solubility

Methanol: 50 mg/mL, clear, colorless

Form

Powder

Pka

11.90±0.20(Predicted)

Color

White

Water Solubility

0.3mg/L(37 ºC)

λmax

227nm(MeOH)(lit.)

Merck

14,6982

BRN

1420457

Stability

Stable. Incompatible with strong oxidizing agents. Combustible.

InChIKey

RCINICONZNJXQF-MZXODVADSA-N

LogP

3.950 (est)

CAS DataBase Reference

33069-62-4(CAS DataBase Reference)

EPA Substance Registry System

Paclitaxel (33069-62-4)


Safety Information

PropertyValue

Hazard Codes

Xn

Risk Statements

37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22

Safety Statements

22-26-36/37/39-45

RIDADR

1544

WGK Germany

3

RTECS

DA8340700

F

10-21

HazardClass

6.1(b)

PackingGroup

III

HS Code

29329990

Hazardous Substances Data

33069-62-4(Hazardous Substances Data)

Toxicity

LD50 intraperitoneal in mouse: 128mg/kg


Product Usage

Paclitaxel is a potent antineoplastic agent originally derived from the Pacific yew tree, widely regarded as a cornerstone in clinical oncology. Its primary application is the treatment of various malignancies, including breast, ovarian, and non-small cell lung cancers, by stabilizing microtubules and inhibiting cell division. In the pharmaceutical industry, it is formulated into sophisticated drug delivery systems, such as albumin-bound particles (nab-paclitaxel), to enhance solubility and reduce side effects. Beyond systemic chemotherapy, Paclitaxel is extensively used in the medical device sector, specifically as a coating for drug-eluting stents and balloons to prevent restenosis in cardiovascular procedures. Its critical role extends to biomedical research, where it serves as a fundamental tool for studying cytoskeleton dynamics and developing next-generation targeted cancer therapies.

Factory Showcase

详情-工厂

Shipping And Transportation

详情-物流

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