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(-)-Epigallocatechin gallate

(-)-Epigallocatechin gallate

Basic Information

CAS No.: 989-51-5
Molecular Formula: C22H18O11
Molecular Weight: 458.37

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Product Details

(-)-epigallocatechin 3-gallate is a gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.  It has a role as an antineoplastic agent, an antioxidant, a Hsp90 inhibitor, a neuroprotective agent, a plant metabolite, a geroprotector and an apoptosis inducer.  It is a gallate ester, a polyphenol and a member of flavans.  It is functionally related to a (-)-epigallocatechin.


Chemical Properties
PropertyValue

Melting point

222-224°C

Alpha

D -185 ±2°(ethanol)

Refractive index

-175.5 ° (C=1, EtOH)

Storage temp.

2-8°C

Solubility

H2O: ≥5mg/mL, clear

Form

Solid

Boiling point

909.1±65.0 °C(Predicted)

Density

1.90±0.1 g/cm3(Predicted)

PKa

7.75±0.25(Predicted)

Color

White to Light Brown

Biological source

Green tea

Water Solubility

Soluble in ethanol, dimethyl formamide, water.

Merck

14,3526

Stability

Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

InChIKey

WMBWREPUVVBILR-WIYYLYMNSA-N

LogP

0.639 (est)

CAS DataBase Reference

989-51-5(CAS DataBase Reference)


Safety Information

PropertyValue

Safety Statements

24/25

WGK Germany

2

RTECS

KB5200000

F

10-23

HS Code

29339900

Toxicity

LD50 oral in mouse: 2170mg/kg


Product Usage

(-)-Epigallocatechin gallate (EGCG), the most abundant and potent catechin found in green tea, is a world-renowned antioxidant widely utilized in the nutraceutical and functional food industries. It is a primary active ingredient in dietary supplements aimed at weight management, metabolic support, and cardiovascular protection. In the cosmetic and dermo-pharmaceutical sector, EGCG is highly prized for its anti-inflammatory and photoprotective properties, often incorporated into high-end skincare formulations to prevent UV-induced damage and slow the signs of aging. Beyond consumer goods, it plays a vital role in biomedical research, where it is studied for its potential in cancer prevention and its ability to inhibit protein misfolding in neurodegenerative diseases. Additionally, its natural antimicrobial properties make it an effective food preservative, helping to extend shelf life and maintain the nutritional integrity of processed oils and fats.

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