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Dextran

Dextran

Basic Information

CAS No.: 9004-54-0
Molecular Formula: C17H32O10
Molecular weight: 396.42998

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Product Details

Dextran, a glucose polymer composed predominantly of ol-1,6-glucopyranosidic linkages, is produced from sucrose by Leuconostoc mesenteroides and related organisms and from dextrins by other bacteria.

Dextran is used in a bead form to aid in bioreactor applications, some size-exclusion chromatography matrices and in osmotic stress technique study involved in biological molecules. It can be used as a stabilizing coating to protect metal nanoparticles from oxidation.

Dextrans are long-chain glucose polysaccharides of various relative molecular masses. Dextran 70 (relative molecular mass 70 000) is retained in the intravascular space where, like albumin, it contributes to the colloid oncotic pressure of plasma. Unlike albumin, dextran 70, when given in large amounts, prevents platelet aggregation and facilitates fibrinolysis.


Chemical Properties
PropertyValue

Melting point

483 °C (decomp)

Alpha

198 º

Density

1.00-1.20g/mL

Refractive index

185 ° (C=6, H2O)

Storage temp.

2-8°C

Solubility

H2O: soluble50mg/mL, clear to very slightly hazy, colorless to faintly yellow

Form

Solid

Color

White to slightly off-white

PH

2 - 10

Biological source

Bacterial (Leuconostoc mesenteroides)

Ooptical activity

+208 to +233 (formaldehyde)

Water Solubility

Soluble in water, dimethyl sulfoxide, ethylene glycol and glycerol.

Merck

14,2948

Stability

Stable. Keep dry. Incompatible with strong oxidizing agents.

LogP

-4.259 (est)

EPA Substance Registry System

Dextran (9004-54-0)

Absorption

≤0.05 at 375nm in H2O at 10%


Safety Information

PropertyValue
Hazard symbolsXn, Xi
Hazard class codes20/21/22-36/37/38
Safety descriptions24/25-37/39-36-26
WGK Germany2
RTECS numberHH9230000
F3
TSCATSCA listed
HS code39139000
Storage class11 - Combustible solids
ToxicityLD50 oral in rat: >3 g/kg


Product Usage

Dextran is a natural polysaccharide produced by microbial fermentation and is widely used in pharmaceuticals, food, and cosmetics. In the pharmaceutical industry, it is commonly used as a plasma volume expander and drug carrier, helping to improve microcirculation and enhance drug stability. In the food industry, dextran functions as a thickener, stabilizer, and moisture-retaining agent, improving texture and mouthfeel. In cosmetics, it offers excellent moisturizing and film-forming properties, helping to strengthen the skin barrier and enhance hydration. It is widely used in formulations such as lotions, creams, and serums.

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