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2-Deoxy-D-glucose

2-Deoxy-D-glucose

Basic Information

CAS No.: 154-17-6
Molecular Formula: C6H12O5
Molecular weight: 164.16

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Product Details

2-Deoxy-D-glucose is an anti-metabolite of D-glucose. It has the effects of interfering with the synthesis of virus-specific glycoproteins, inhibiting the proliferation of herpes simplex virus, RAN and DNA enveloped viruses, and cancer cells. At present, antiviral and anticancer drugs prepared from 2-deoxy-D-glucose have been clinically used in the treatment of herpes simplex virus and cancer, and medical health products and anti-aging cosmetics prepared from 2-deoxy-D-glucose have also been launched on the market. 2-Deoxy-D-glucose has no toxic side effects and is widely used in medical health products, anti-aging cosmetics and life science research. It has huge market potential and good development prospects.


Chemical Properties

PropertyValue

Melting point

146-147 °C(lit.)

Alpha

45.5 º (c=2, H2O)

Boiling point

211.61°C (rough estimate)

Density

1.1738 (rough estimate)

Refractive index

46.5 ° (C=1, H2O)

Storage temp.

2-8°C

Solubility

H2O: 50 mg/mL, clear, colorless to faintly yellow

Form

Crystalline

Pka

pK1:12.52 (25°C)

Color

White

Water Solubility

Soluble in water.

Merck

14,2904

BRN

1723331

Stability

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used within 1 working day.

InChIKey

PMMURAAUARKVCB-CEZCPVKQSA-N

LogP

-1.460 (est)

CAS DataBase Reference

154-17-6(CAS DataBase Reference)

EPA Substance Registry System

D-arabino-Hexose, 2-deoxy- (154-17-6)


Safety Information

PropertyValue

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

24/25-37/39-36-26

WGK Germany

3

RTECS

MQ3325000

F

3-10

TSCA

Yes

HS Code

29400090

Hazardous Substances Data

154-17-6(Hazardous Substances Data)


Product Usage

2-Deoxy-D-glucose (2-DG) is a glucose molecule in which the 2-hydroxyl group is replaced by hydrogen, acting as a potent glycolytic inhibitor. Its primary application is in biomedical research and drug development, where it is used to study cellular metabolism and explore anti-tumor strategies by starving cancer cells of energy. In the pharmaceutical sector, it has gained significant attention as an antiviral agent, specifically for its potential to interfere with viral replication. Additionally, it is an essential diagnostic tool in medical imaging, serving as a precursor or analog in PET scans to identify areas of high glucose consumption. Beyond clinical use, 2-DG is utilized in biotechnology as a selection agent in yeast and fungal genetics and as a stabilizer in specialized biochemical formulations.

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