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L-Leucine

L-Leucine

Basic Information

CAS No.: 61-90-5
Molecular Formula: C6H13NO2
Molecular Weight: 131.17

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Product Details

L-leucine is one of the eight essential amino acids, and belonging to the aliphatic amino acids within twenty kinds of proteins. L-leucine and L-isoleucine and L-valine are called three branched chain amino acids. L-leucineLeucine and D-leucine are enantiomers . It is a white shiny hexahedral crystal or white crystalline powder at room temperature , Odorless, slightly bitter .


Chemical Properties
PropertyValue

Melting point

>300 °C (lit.)

Alpha

15.4 º (c=4, 6N HCl)

Boiling point

122-134 °C(Press: 2-3 Torr)

Bulk density

300-400kg/m3

Density

1,293 g/cm3

Vapor pressure

<1 hPa (20 °C)

Refractive index

1.4630 (estimate)

FEMA

3297 | L-LEUCINE

Fp

145-148°C

Storage temp.

2-8°C

Solubility

1 M HCl: 50 mg/mL

Form

Powder

Pka

2.328(at 25℃)

Color

White to Off-white

Odor

at 100.00?%. odorless

PH

5.5-6.5 (20g/l, H2O, 20℃)

Biological source

Plant

Optical Rotation

[α]20/D +15.5°, c = 2 in 6 M HCl

Water Solubility

22.4 g/L (20 C)

λmax

λ: 260 nm Amax: 0.05λ: 280 nm Amax: 0.05

JECFA Number

1423

Sublimation

145-148 ºC

Merck

14,5451

BRN

1721722

Stability

Stability Moisture and light sensitive. Incompatible with strong oxidising agents.

LogP

0.80

CAS DataBase Reference

61-90-5(CAS DataBase Reference)

NIST Chemistry Reference

Leucine(61-90-5)

EPA Substance Registry System

L-Leucine (61-90-5)


Safety Information

PropertyValue

Safety Statements

24/25

WGK Germany

3

RTECS

OH2850000

TSCA

Yes

HS Code

29224995

Hazardous Substances Data

61-90-5(Hazardous Substances Data)


Product Usage

L-Leucine is an essential branched-chain amino acid (BCAA) that plays a critical role in protein synthesis and muscle repair. Its primary application is in the sports nutrition and dietary supplement industry, where it is hailed as the most potent activator of the mTOR signaling pathway, directly stimulating muscle protein synthesis for athletes and bodybuilders. In the pharmaceutical sector, L-Leucine is used as a key component in parenteral nutrition (IV drips) and for treating liver diseases and muscle wasting conditions. In infant formula, it is an indispensable additive to support healthy growth and metabolic development. Furthermore, it serves as a specialized lubricant in the tableting process for the pharmaceutical and food industries, and as a starting material for synthesizing various flavorings and biochemical reagents.

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