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D-α-Tocopherol succinate

D-α-Tocopherol succinate

Basic Information

CAS No.: 4345-03-3
Molecular Formula: C33H54O5
Molecular Weight: 530.78

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Product Details

Tocopherol succinate (4345-03-3) is a potent antioxidant.  Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2? Tocopherol succinate induces apoptosis in human gastric cancer cells3? and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14.  Induces apoptosis in neuroblastoma cells.5


Chemical Properties
PropertyValue

Melting point

~76 °C(lit.)

Boiling point

625.8±55.0 °C(Predicted)

Density

1.002±0.06 g/cm3(Predicted)

Vapor pressure

0Pa at 20℃

Storage temp.

-20°C

Solubility

Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol.

Form

Solid

Pka

4.35±0.17(Predicted)

Color

White or off-white

Odor

Little or no odor

Biological source

synthetic

λmax

286nm(EtOH)(lit.)

Merck

14,9495

BRN

4038233

Specific Activity

1210IU/g

Stability

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

LogP

12 at 25℃

CAS DataBase Reference

4345-03-3(CAS DataBase Reference)

EPA Substance Registry System

D-.alpha.-Tocopheryl acid succinate (4345-03-3)


Safety Information

PropertyValue

WGK Germany

1

RTECS

EJ9984000

F

8-10-23

HS Code

2936280000

Toxicity

LD50 oral in rat: > 7gm/kg


Product Usage

D-α-Tocopherol succinate, a solid derivative of natural Vitamin E, is highly valued for its superior stability and potent biological activity. Its primary application is in the pharmaceutical and nutraceutical industries, where it is a preferred form of Vitamin E for high-end dietary supplements, tablets, and hard capsules due to its non-oily, crystalline nature. Beyond basic nutritional fortification, it is extensively researched and utilized for its anti-tumor properties and ability to induce apoptosis in cancer cells without harming normal tissues. In the cosmetic sector, it serves as a powerful antioxidant and skin-conditioning agent, protecting cell membranes from oxidative damage and UV-induced stress. Furthermore, it is used in functional foods and animal nutrition to enhance shelf life and support immune function, offering better resistance to heat and oxidation compared to liquid Vitamin E.

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