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Trifluoroacetamide

Trifluoroacetamide

Basic Information

CAS No.: 354-38-1
Molecular Formula: C2H2F3NO
Molecular Weight: 113.039

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Product Details

Trifluoroacetamide has a melting point of approximately 72-75℃ and a boiling point of about 162-164℃. It is readily soluble in water, ethanol, ether and other polar organic solvents. It possesses the typical chemical properties of amide compounds. Meanwhile, due to the presence of trifluoromethyl (-CF₃), it has certain stability and special reactivity. For instance, in organic synthesis, it can be used as an acylation reagent or a protecting group.


Chemical Properties

PropertyValue

Melting point

65-70 °C (lit.)

Boiling point

162.5 °C (lit.)

Density

1.4176 (estimate)

Bulk density

960kg/m3

Fp

162-164°C

Storage temp.

Store below +30°C.

Solubility

460 g/L (20°C)

Pka

12.33±0.50(Predicted)

Form

Crystalline Powder or Crystals

Color

White to pale yellow or beige

PH

3.6 (460g/l, H2O, 23℃)

Water Solubility

460 g/L (20 ºC)

BRN

1753625

InChIKey

NRKYWOKHZRQRJR-UHFFFAOYSA-N

LogP

0.725 at 23℃ and pH4.83

Dissociation constant

0 at 23℃

CAS DataBase Reference

354-38-1(CAS DataBase Reference)

NIST Chemistry Reference

Acetamide, 2,2,2-trifluoro-(354-38-1)

EPA Substance Registry System

Acetamide, 2,2,2-trifluoro- (354-38-1)


Safety Information

PropertyValue

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36-37/39

RIDADR

1759

WGK Germany

3

Hazard Note

Harmful/Irritant

TSCA

T

HazardClass

8

PackingGroup

III

HS Code

29241900


Product Usage

Trifluoroacetamide is a specialized fluorinated intermediate widely utilized in high-end organic synthesis. Its primary application is in the pharmaceutical industry, where it serves as a critical building block for introducing trifluoromethyl groups into bioactive molecules, enhancing their metabolic stability and lipophilicity. In agrochemical manufacturing, it is an essential precursor for synthesizing high-efficiency herbicides, insecticides, and fungicides. Furthermore, it acts as a versatile protecting group reagent in peptide synthesis and organic chemical reactions. In the field of material science, trifluoroacetamide is employed in the development of fluorinated polymers and specialty electronic chemicals, valued for their unique dielectric properties and thermal resistance.

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