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Neomycin Sulfate

Neomycin Sulfate

Basic Information

CAS No.: 1405-10-3
Molecular Formula: C23H48N6O17S
Molecular Weight: 712.72

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Product Details

Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria. Neomycin sulfate inhibits PLC (Phospholipase C) via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation. It is used to prevent or treat skin infections caused by bacteria. It is not effective against fungal or viral infections.


Chemical Properties
PropertyValue

Melting point

>187°C (dec.)

Alpha

D20 +54° (c = 2 in H2O)

Bulk density

640kg/m3

Refractive index

56 ° (C=10, H2O)

Fp

56℃

Storage temp.

2-8°C

Solubility

H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.

Form

Powder

Color

White to slightly yellow

PH

5.0-7.5 (50g/l, H2O, 20℃)

Biological source

Streptomyces sp.

Water Solubility

Soluble in water

Merck

14,6454

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

OIXVKQDWLFHVGR-VTSVPHRWSA-N

LogP

-3.655 (est)

CAS DataBase Reference

1405-10-3(CAS DataBase Reference)

EPA Substance Registry System

Neomycin sulfate (1405-10-3)


Safety Information

PropertyValue

Hazard Codes

Xn,Xi

Risk Statements

42/43-22

Safety Statements

23-36/37-45-22-36-24/25

WGK Germany

3

RTECS

QP4375000

F

8

TSCA

Yes

HS Code

29419000

Toxicity

LD50 oral in mouse: > 8gm


Product Usage

Neomycin Sulfate is a broad-spectrum aminoglycoside antibiotic primarily used for its potent antibacterial activity against Gram-negative and some Gram-positive bacteria. In the pharmaceutical industry, its most common application is in topical formulations, including ointments, creams, and eye drops, to treat skin infections, wounds, and ocular inflammations. Due to its poor absorption in the digestive tract, it is also administered orally as an intestinal antiseptic to suppress bacterial flora before abdominal surgery or to manage hepatic encephalopathy. Furthermore, it is widely utilized in veterinary medicine to treat gastrointestinal infections in livestock and as a selective agent in molecular biology research to prevent microbial contamination in cell cultures.


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