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Natamycin

Natamycin

Basic Information

CAS No.: 7681-93-8
Molecular Formula: C33H47NO13
Molecular Weight:665.73

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Product Details

Pimaricin (also known as natamycin, INN) belongs to a naturally occurring antifungal agent produced through the fermentation of the bacterium Streptomyces natalensis. It is a kind of macrolide polyene antifungal used for the treatment of fungal keratitis, which is a kind of eye infection.


Chemical Properties

PropertyValue

Melting Point

2000C (dec)

Alpha

D20 +278° (c = 1 in CH3COOH)

Boiling Point

952℃

Bulk Density

200kg/m3

Ddensity

1.0 g/mL at 20 °C(lit.)

Refractive Index

1.5960 (estimate)

Fp

>110°(230°F)

Storage Temp.

Keep in dark place,Inert atmosphere,2-8°C

sSolubility

Soluble in DMSO

Form

aqueous suspension

Pka

pKa 4.6(50% aq. MeOEtOH) (Uncertain);8.35 (Uncertain)

Color

Cream colored

Water Solubility

0.41g/L(21 ºC)

Sensitive

Light Sensitive

Merck

13,6453

BRN

1614878

Stability:

Light sensitive

InChIKey

NCXMLFZGDNKEPB-FFPOYIOWSA-N

LogP

0.880 (est)

EPA Substance Registry System

6,11,28-Trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid, 22-[(3-amino-3,6-dideoxy-.beta.-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-, (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)- (7681-93-8)


Safety Information

Property

Value
Hazard symbolXn
Hazard class codes22
Safety descriptions24/25-36
WGK Germany2
RTECS numberTK3325000
F8-10
HS code29419090
Storage class11 - Combustible solids
ToxicityLD50 orally in male, female rats (g/kg): 2.73, 4.67 (Levinskas)


Product Usage

Natamycin, also known as Pimaricin, with CAS No. 7681-93-8 and chemical formula C₃₃H₄₇NO₁₃, is a white or pale yellow crystalline powder, a natural polyene antifungal agent produced by Streptomyces natalensis. Its core applications cover food preservation, medical treatment and agriculture. In the food industry, it inhibits the growth of molds and yeasts in cheese, meat products and pastries, prevents mycotoxin production without affecting food flavor and beneficial bacteria. In medical field, 5% ophthalmic suspension treats fungal blepharitis, conjunctivitis and keratitis. It is also used for crop mildew prevention. High in safety, it is hardly absorbed by human digestive tract, certified by food safety authorities worldwide, and is a natural and efficient functional raw material.

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