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Amide

Amide

Basic Information

CAS No.: 166407-85-8
Molecular Formula: C23H21NO2
Molecular Weight: 343.4

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Product Details

Amides are organic compounds in which the hydroxyl group of a carboxylic acid is replaced by an amino or amine group. They are mainly used as industrial solvents. Structurally, amides can be regarded as compounds in which the hydroxyl group of the carboxyl group in a carboxylic acid molecule is replaced by an amino or hydrocarbon amino group (-NHR or -NR2); they can also be regarded as compounds in which the hydrogen atom on the nitrogen atom in an ammonia or amine molecule is replaced by an acyl group.


Basic Information

ItemContent
English Name2-(3-Benzoylphenyl)-N-benzylpropanamide
CAS No.166407-85-8
Molecular FormulaC23H21NO2
Molecular Weight343.42
Functional GroupsAmide bond, aromatic ketone group, benzene ring


Physical and Chemical Properties

AppearanceWhite to off-white crystalline powder
Melting Point118~122℃
DensityApprox. 1.18 g/cm³ (25℃)
Water SolubilityPractically insoluble in water
SolubilityEasily soluble in ethanol, ethyl acetate, dichloromethane, tetrahydrofuran and other organic solvents
StabilityStable under normal temperature and pressure
VolatilityLow volatility


Main Chemical Properties

Reaction TypeCharacteristics
Hydrolysis ReactionBelongs to secondary amide, stable at room temperature; hydrolyzes under heating with strong acid or strong base to generate corresponding carboxylic acid and benzylamine
Reduction ReactionKetone carbonyl group can be reduced by sodium borohydride; amide bond is hard to be reduced by common reducing agents
Acid-base PropertyNeutral overall, no obvious acidity or alkalinity
PolymerizationNo polymerization activity
Oxidation ReactionAromatic ring is prone to oxidation reaction under strong oxidant condition
Substitution ReactionElectrophilic substitution reaction can occur on benzene ring


Safety Information

CategoryDetails
ToxicityLow toxicity, no acute high toxicity data
Contact HazardsMild irritation to skin, eyes and respiratory tract
Routes of EntryInhalation, skin contact, ingestion
Flammability & Explosion HazardCombustible; releases toxic fumes including nitrogen oxides and carbon monoxide when burned at high temperature
First-aid MeasuresSkin contact: Rinse with plenty of clean water; Eye contact: Flush eyes thoroughly with water and seek medical advice; Inhalation: Move to fresh air immediately
Protective MeasuresWear dust-proof mask, rubber gloves and safety goggles; operate in well-ventilated place
Storage ConditionsSeal and store in cool dry place, keep away from heat source, strong acid, strong base and strong oxidants
Waste DisposalDispose as hazardous organic chemical waste, do not dump randomly
Incompatible SubstancesStrong acids, strong alkalis and strong oxidizing substances



Product Usage

Amides are a class of organic compounds containing the -CONH2 group, widely used in pharmaceuticals, materials, chemicals, and agriculture. Their main applications include as active pharmaceutical ingredients, monomers for polymer materials, industrial solvents, and pesticides.

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