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Collagenase

Name: Collagenase
SKU: 0

Basic Information

CAS No.: 9001-12-1
Molecular Formula: C60H100N2
Molecular Weight: 849.474

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Product Details

Collagenase, also known as collagenase and clostridial peptidase, is a protease obtained by fermentation of Clostridium histolyticum.

Medical collagenase is refined from the culture fluid of Clostridium histolyticum ATCC21000. This enzyme has high decomposition activity on the peptide bond of the gly-pro sequence.

Due to the breakage of the original collagen molecule, it provides good conditions for the hydrolysis of other proteases, making it have the unique function of hydrolyzing collagen and denaturing collagen.

The medical enzyme made from this enzyme has the ability to digest natural collagen and denatured collagen, has a strong digestive effect on necrotic tissue, and can promote the growth of granulation and epithelial cells.

This product has no effect on globulin and fibrin, so it does not affect the normal blood vessels and muscle tissue of the human body. It can be used to treat debridement, scab removal, chronic skin ulcers, bedsores, etc. of II and III degree burns.

Chemical Properties

Property	Value
Storage Temp.	-20°C
Solubility	Soluble in aqueous buffers.
Form	powder
Color	light brown
PH	7.0
Merck	2481
InChIKey	YRQNKMKHABXEJZ-UVQQGXFZSA-N
CAS DataBase Reference	9001-12-1
EPA Substance Registry System	Collagenase (9001-12-1)

Safety Information

Property	Value
Hazard Codes	Xn
Risk Statements	36/37/38-42
Safety Statements	22-24-26-36/37
WGK Germany	1
F	10-21
HS Code	3507907000

Product Usage
Collagenase is a protease that can specifically degrade collagen. It mostly appears as white to pale yellow powder, is easily soluble in water, has high specific catalytic activity and high safety. Its core application is in the medical field, often used in the repair of wounds such as burns and chronic ulcers. It can degrade necrotic collagen in wounds, remove carrion, promote granulation tissue growth, and accelerate wound healing; it is also used in surgical operations to assist in tissue separation and reduce postoperative adhesion. In the field of biological research, it is used for tissue dispersion during cell culture to help obtain single viable cells and facilitate the conduct of cell biology experiments. In addition, it is used in the cosmetics field to gently decompose aged collagen on the skin surface, improve skin roughness and fine lines, and enhance skin elasticity; it is used for meat tenderization in the food industry, and is a versatile functional protease raw material in multiple fields.

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Collagenase

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